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BioTE HER-T - Hormone Support - 30 Capsules

BioTE HER T - Hormone Support

Biote Her-T is a naturally derived, optimally balanced, science-based combination of Pyridoxine (Vitamin B), Cholecalciferol (Vitamin D,), Zinc (Zn), Luteolin, Secoisolariciresinol Diglucoside (SDG), Gingerols/6-Gingerol, and Spermidine. This physician-grade formulation supports healthy testosterone balance, helps balance cortisol levels, decreases inflammation and oxidative stress, and supports overall health and longevity.

Supports Multi-Mechanistic Hormone Balance:

  • Selective estrogen receptor modulation (SERM)
  • Prolactin
  • Aromatase
  • Five-alpha reductase Luteinizing hormone

DIM, short for diindolylmethane, is a hormone “balancer.” DIM SGS+ derives from broccoli and pomegranate. However, it is not a plant estrogen or an estrogen mimic, like soy isoflavones. DIM stimulates more efficient metabolism for estrogen.  Meaning it could help regulate the ratio of healthy to less healthy estrogen.

What are the main ingredients of Biote Her-T?

Pyridoxine (Vitamin B)

Research suggests vitamin B supports healthy testosterone levels by modulating cortisol and prolactin. Both prolactin and cortisol decrease testosterone production.  It has been suggested that vitamin B, significantly reduces prolactin levels, which reduces prolactin’s inhibitory effects on testosterone synthesis.  Studies also show that vitamin B, may modulate elevated cortisol levels by inhibiting glucocorticoid receptors. This in turn, decreases cortisol receptor binding and its adverse effects on testosterone production.

Cholecalciferol (Vitamin D)

The available evidence in men indicates that vitamin D3, a prohormone, is associated with total and free testosterone levels, i.e., as vitamin D levels increase, so do total and free testosterone levels, and as vitamin D levels decrease, so does testosterone.  Notably, in one study
vitamin D3 supplementation resulted in significantly higher total and free testosterone levels in middle-aged men.

Zinc (Zn)

In addition to its immune modulatory functions, zinc, an essential mineral, is a cofactor for luteinizing hormone (LH) synthesis, LH release, and testosterone production. Hence, zinc deficiency may impair LH synthesis and testosterone production. Zinc deficiency may also increase estrogen receptor expression. Zinc supplementation (30mg/d) in men with marginal zinc deficiency nearly doubled total testosterone levels. In addition, zinc inhibits 5-alpha reductase, the enzyme that converts testosterone to its more potent metabolite 5-alpha dihydrotestosterone (DHT). This inhibitory effect may be potentiated by vitamin B6.


Luteolin, a flavone chemical class phytochemical isolate, is found in terrestrial plant families, including Asteraceae, Fabaceae, and Lamiaceae. Luteolin is involved in optimizing testosterone levels via multiple mechanisms.

Secoisolariciresinol Diglucoside (SDG)

The lignan chemical class phytochemical secoisolariciresinol diglucoside (SDG) has been shown to inhibit aromatase, the enzyme that converts testosterone to estradiol, which decreases testosterone levels.  Research suggests that enterolactone, SDG’s primary metabolite, is a potent 5-alpha reductase inhibitor.  The latter maintains testosterone levels by preventing testosterone metabolism to dihydrotestosterone (DHT). Studies have shown that SDG, especially in high concentrations, can decrease cortisol levels in response to mental stress.  In one in vivo study, high-dose SDG eliminated the stress-induced cortisol increase.
Cortisol and testosterone have an inverse relationship. As cortisol increases, testosterone production decreases. Therefore, supporting healthy cortisol levels helps support healthy testosterone balance. In addition, lignan chemical class phytochemicals, including SDG, function as selective estrogen receptor modulators (SERMs), which, in men, support healthy hormone-sensitive prostate tissue.


The phytochemical class gingerols, which includes 6-gingerol isolate, are compounds derived from the root of the terrestrial plant family Zingiberaceae. Gingerols act as bio-active anti-inflammatory and antioxidant compounds. A recent scientific review found that supplementation with Zingiber officinale root concentrate, particularly in individuals with accelerated oxidative stress, increased testosterone production by increasing luteinizing hormone (LH) production. Specifically, 6-gingerol can modulate testosterone levels by supporting a decrease in inflammation and oxidative stress. Six-gingerol upregulates nuclear factor erythroid 2-related factor (Nrf2), the master regulator of endogenous antioxidant enzyme production. In addition, 6-gingerol inhibits cyclooxygenase-2 (COX-2), a proinflammatory enzyme that increases with age and negatively impacts testosterone production. Further, 6-gingerol significantly increased nitric oxide (NO) production, which stimulates cyclic adenosine monophosphate (cGMP), resulting in enhanced blood flow and vasodilation, which may stimulate testosterone production.


Spermidine, a polyamine chemical class compound, is a natural substance produced by every living cell, whether plant or animal. Spermidine is the most abundant polyamine that is required for life. However, spermidine decreases with age. High dietary intake of spermidine and related polyamines are associated with improved health and longevity, thus considered a true “anti-aging” molecule. The effects are like caloric restriction, which is a robust and consistent anti-aging modality. Importantly, testosterone supports increased spermidine synthesis and reduced testosterone levels are associated with lower spermidine levels. Research has shown that spermidine supplementation increased men’s testosterone levels by approximately 50%, along with a decrease in cortisol levels approximating 50%.

Suggested Use: Take 1 capsule daily in the AM with a light meal or snack, as a dietary supplement, or as your healthcare provider recommends.

Does Not Contain: Soy, Dairy, Gluten, Wheat, Egg, Corn, Tree Nuts, Peanuts, Shellfish, Fish, Sesame, Artificial Colorings or Flavorings.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.